Can't argue with MP.
Running/spitting out the audio tracks to a firewire drive is a very good move. 10,000 rpm even better again.........multi platter drive system better again but there is a limit to budget vs gain........and another drive hopefully at least 7200 is a very good start.....bus powered would be very portable.
Once you start reaching the Powerbooks' limits there are tricks like turning off scrolling, not having a track open to record as this takes away CPU, launch with option key down to disable notation, automatic midi thru, audio thru switches etc and keep effects installed to a minimum.
Heaps of RAM always helps
Reading your message again........running midi files you should be fine with a standard PB.
You do start taxing a system when running heaps of samples like using soundfonts of highquality as replacement sounds for your midi instruments/tracks. A 1.5Ghz machine is probably ok.